IFIH1 Antibody - middle region

Article Name:	IFIH1 Antibody - middle region
Biozol Catalog Number:	ASB-ARP36486_P050
Supplier Catalog Number:	ARP36486_P050
Alternative Catalog Number:	ASB-ARP36486_P050-25UL,ASB-ARP36486_P050-100UL
Manufacturer:	Aviva
Host:	Rabbit
Category:	Proteine/Peptide
Application:	IHC, WB
Species Reactivity:	Bovine, Equine, Human, Mouse, Porcine, Rat
Immunogen:	The immunogen is a synthetic peptide directed towards the middle region of human IFIH1
Alternative Names:	AGS7, Hlcd, MDA5, MDA-5, RLR-2, IDDM19, SGMRT1

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. IFIH1 is a DEAD box protein that is upregulated in response to treatment with beta-interferon (IFNB) and a protein kinase C-activating compound, mezerein (MEZ). Irreversible reprogramming of melanomas can be achieved by treatment with both these agents, treatment with either agent alone only achieves reversible differentiation.DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that is upregulated in response to treatment with beta-interferon (IFNB) and a protein kinase C-activating compound, mezerein (MEZ). Irreversible reprogramming of melanomas can be achieved by treatment with both these agents, treatment with either agent alone only achieves reversible differentiation. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Clonality:	Polyclonal
Concentration:	0.5 mg/ml
Molecular Weight:	117kDa
NCBI:	64135
UniProt:	Q9BYX4
Form:	Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

	IHC Information: Paraffin embedded spleen tissue, tested with an antibody Dilution of 5 ug/ml.
	WB Suggested Anti-IFIH1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: Human Muscle
	Lanes: 1: 20ug HEK293T no transfection, 2: 20ug HEK293T 3Flag-MDA5/IFIH1 Primary Antibody Dilution: 1:1000 Secondary Antibody: Anti-rabbit HRP Secondary Antibody Dilution: 1:1000 Gene Name: IFIH1 Submitted by: Dr. Safia Deddouche, London Research Institute IFIH1 is supported by BioGPS gene expression data to be expressed in HEK293T
	IFIH1 antibody - middle region (ARP36486_P050) in Human Muscle using Western Blot