MBD2 Antibody - N-terminal region
Catalog Number:
ASB-ARP32485_P050
- Images (4)
| Article Name: | MBD2 Antibody - N-terminal region |
| Biozol Catalog Number: | ASB-ARP32485_P050 |
| Supplier Catalog Number: | ARP32485_P050 |
| Alternative Catalog Number: | ASB-ARP32485_P050-25UL,ASB-ARP32485_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | IHC, WB |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | The immunogen is a synthetic peptide directed towards the N terminal region of human MBD2 |
| Alternative Names: | DMTase, NY-CO-41 |
| MBD2 belongs to a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD2 can also repress transcription from methylated gene promoters. MBD2 may function as a mediator of the biological consequences of the methylation signal.It is also reported that the MBD2 functions as a demethylase to activate transcription, as DNA methylation causes gene silencing.DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. |
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Rabbit Anti-MBD2 Antibody Catalog Number: ARP32485_P050 Formalin Fixed Paraffin Embedded Tissue: Human Adult liver Observed Staining: Nuclear Primary Antibody Concentration: 1:100 Secondary Antibody: Donkey anti-Rabbit-Cy2/3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 a€'' 2.0 sec Protocol located in Reviews and Data. |
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WB Suggested Anti-MBD2 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:12500 Positive Control: 721_B cell lysateMBD2 is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells |
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Lanes: Lane 1: 15ug WT mouse ES lysate Lane 2: 15ug MBD2 KO mouse ES lysate Primary Antibody Dilution: 1:1000 Secondary Antibody: Goat anti-rabbit-HRP Secondary Antibody Dilution: 1:2500 Gene Name: MBD2 a Submitted by: Austin J. Cooney, Baylor College of Medicine |
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MBD2 antibody - N-terminal region (ARP32485_P050) in Human 721_B using Western Blot |
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