E2F4 Antibody - C-terminal region
Catalog Number:
ASB-ARP31175_P050
- Images (4)
| Article Name: | E2F4 Antibody - C-terminal region |
| Biozol Catalog Number: | ASB-ARP31175_P050 |
| Supplier Catalog Number: | ARP31175_P050 |
| Alternative Catalog Number: | ASB-ARP31175_P050-25UL,ASB-ARP31175_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | IHC, WB |
| Species Reactivity: | Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat, Zebrafish |
| Immunogen: | The immunogen is a synthetic peptide directed towards the C terminal region of human E2F4 |
| Alternative Names: | E2F-4 |
| The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins. It is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It also plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. |
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Human Intestine |
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Human Stomach |
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WB Suggested Anti-E2F4 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: HepG2 cell lysate |
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E2F4 antibody - C-terminal region (ARP31175_P050) in Human HepG2 using Western Blot |
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