BUB3 Antibody, Rabbit, Polyclonal
Catalog Number:
ABT-AP51023
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| Article Name: | BUB3 Antibody, Rabbit, Polyclonal |
| Biozol Catalog Number: | ABT-AP51023 |
| Supplier Catalog Number: | AP51023 |
| Alternative Catalog Number: | ABT-AP51023-100UL |
| Manufacturer: | Abcepta |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | WB |
| Species Reactivity: | Human |
| Alternative Names: | Mitotic checkpoint protein BUB3, BUB3 |
| Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. |
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