CLK2 Antibody, Rabbit, Polyclonal
Catalog Number:
ABT-AP50695
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| Article Name: | CLK2 Antibody, Rabbit, Polyclonal |
| Biozol Catalog Number: | ABT-AP50695 |
| Supplier Catalog Number: | AP50695 |
| Alternative Catalog Number: | ABT-AP50695-100UL |
| Manufacturer: | Abcepta |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | WB |
| Species Reactivity: | Human, Mouse, Rat |
| Alternative Names: | Dual specificity protein kinase CLK2, CDC-like kinase 2, CLK2 |
| Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. |
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