Anti-p21/CIP1/WAF1 Antibody, IgG2a, Clone: [M513], Mouse, Monoclonal
Catalog Number:
ABT-AN1874
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| Article Name: | Anti-p21/CIP1/WAF1 Antibody, IgG2a, Clone: [M513], Mouse, Monoclonal |
| Biozol Catalog Number: | ABT-AN1874 |
| Supplier Catalog Number: | AN1874 |
| Alternative Catalog Number: | ABT-AN1874-100UL |
| Manufacturer: | Abcepta |
| Host: | Mouse |
| Category: | Antikörper |
| Application: | IF, IHC, WB |
| Alternative Names: | Cyclin-dependent kinase inhibitor 1 CDK-interacting protein 1 Melanoma differentiation-associated protein 6 MDA-6 p21 CDKN1A CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1 |
| The tumor suppressor protein p21/CIP1/WAF1 acts as an inhibitor of cell cycle progression. It functions in stoichiometric relationships forming heterotrimeric complexes with cyclins and cyclin-dependent kinases. In association with CDK2 complexes, it serves to inhibit kinase activity and block progression through G1/S. However, p21 may also enhance assembly and activity in complexes of CDK4 or CDK6 and cyclin D. The carboxy-terminal region of p21 is sufficient to bind and inhibit PCNA, a subunit of DNA polymerase, and may coordinate DNA replication with cell cycle progression. Upon UV damage or during cell cycle stages when cdc2/cyclin B or CDK2/cyclin A are active, p53 is phosphorylated and upregulates p21 transcription via a p53-responsive element. Protein levels of p21 are downregulated through ubiquitination and proteasomal degradation. |
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