Functional CD40 (mouse) Antibody, mAb, Clone: [FGK45], Monoclonal
Catalog Number:
ABT-ADP0024-U0500
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| Article Name: | Functional CD40 (mouse) Antibody, mAb, Clone: [FGK45], Monoclonal |
| Biozol Catalog Number: | ABT-ADP0024-U0500 |
| Supplier Catalog Number: | ADP0024-U0500 |
| Alternative Catalog Number: | ABT-ADP0024-U0500-500UG |
| Manufacturer: | Abcepta |
| Category: | Antikörper |
| Application: | FC |
| Species Reactivity: | Mouse |
| Alternative Names: | Tumor Necrosis Factor Receptor Superfamily Member 5, CD40L Receptor |
| CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. The interaction of CD40-CD40L is necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkins and Hodgkins lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary. |
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