Mouse IL-12 R beta 2 Protein, His Tag (SPR verified), Unconjugated, Human
Biozol Catalog Number:
ABS-ILB-M52H3-1MG
Supplier Catalog Number:
ILB-M52H3-1mg
Alternative Catalog Number:
ABS-ILB-M52H3-1MG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Mouse
Conjugation:
Unconjugated
The human IL12 R subunit is a member of the cytokine receptor superfamily and the functional highaffinity IL12R is composed of at least two betatype cytokine receptor subunits, each independently exhibiting a low affinity for IL12. IL12RB2 is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of Tcells as well as NK cells. Induces the promotion of Tcells towards the Th1 phenotype by strongly enhancing IFNgamma production. IL12B2 gene acts as tumor suppressor in human acute and chronic Bcell leukemias/lymphomas, IL12R beta 2 directly restrains multiple myeloma cell growth, and targeting of IL12 to tumor cells holds promise as new therapeutic strategy. - Proteine/Peptide
