The NC1-H69 human small cell lung carcinoma line was used as immunogen to generate the EpCAM antibody. The antibody binding epitope has been mapped to the first EGF-like repeat domain (EGF1) amino acids 27-59 of the EpCAM protein.
Alternative Names:
EPCAM||GA733-2||M1S2||M4S1||MIC18||TACSTD1||TROP1
EpCAM (epithelial specific antigen) is an ~40 kDa transmembrane glycoprotein involved in a number of cellular processes including adhesion, proliferation, maintenance of stemness, migration and invasion. EpCAM is expressed on most, but not all, normal epithelia and their corresponding malignancies. Although the role of EpCAM expression in tumorigenesis remains to be fully elucidated, EpCAM may downregulate immunity and help tumors actively escape from immune surveillance.
