NCKX3 (Sodium/Potassium/Calcium Exchanger 3, a(+)/K(+)/Ca(2+)-exchange Protein 3, Solute Carrier Family 24 Member 3, SLC24A3), Rabbit
Artikelnummer:
USB-N0559-06A
Hersteller Artikelnummer:
N0559-06A
Alternativnummer:
USB-N0559-06A-100
Hersteller:
US Biological
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
ELISA, WB
Immunogen:
Synthetic peptide corresponding to 16aa near the C-terminal, extracellular domain of human NCKX3 conjugated to KLH. Species Sequence Homology: mouse and rat, 100%
Ca2+ plays a critical role in intracellular signaling. Intracellular Ca2+ levels are tightly controlled by continuos removal of Ca2+ via ATP-driven Ca2+ pump in the endoplasmic reticulum and plasma membrane, and the Na+/Ca2+ exchangers (NCX), in the plasma membrane. NCX can move Ca2+ either into or out of cells, depending on the net Na+, Ca2+, and K+ gradient across the membrane. In most cells, 3 Na+ are exchanged for 1 Ca2+. Several genes code for the 3 NCX (NCX1, NCX2, and NCX3), and three in the NCKX family (NCKX1, NCKX2, NCKX3). NCX share significant sequence homology (~70%), display 11 TM domains, a large central, intracellular hydrophilic regulatory loop between TM5 and 6, extracellular N-terminus and cytoplasmic C-terminus. The N-terminal signal peptide is cleaved off from the mature exchanger protein. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilutions: ELISA: 0.5-1ug/ml. Control peptide can be used to coat ELISA plate at 1ug/ml. Western Blot: 1-10ug/ml (ECL) Optimal dilutions to be determined by the researcher. Control Peptide: N0559-06B: NCKX3, Control Peptide Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Reinheit:
Purified by immunoaffinity chromatography.
Formulierung:
Supplied as a liquid in PBS, 0.1% BSA.
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
