MAP Kinase 15, NT (Mitogen-activated Protein Kinase 15, MAPK 15, MAPK15, Extracellular Signal-regulated Kinase 7, ERK7, ERK-7, Extracellular Signal-regulated Kinase 8, ERK8, ERK-8), Rabbit
Artikelnummer:
USB-M2362-65N
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| Artikelname: | MAP Kinase 15, NT (Mitogen-activated Protein Kinase 15, MAPK 15, MAPK15, Extracellular Signal-regulated Kinase 7, ERK7, ERK-7, Extracellular Signal-regulated Kinase 8, ERK8, ERK-8), Rabbit |
| Artikelnummer: | USB-M2362-65N |
| Hersteller Artikelnummer: | M2362-65N |
| Alternativnummer: | USB-M2362-65N-200 |
| Hersteller: | US Biological |
| Wirt: | Rabbit |
| Kategorie: | Antikörper |
| Applikation: | ELISA, IHC, WB |
| Immunogen: | Synthetic peptide selected from the N-terminal region of human ERK8 (KLH). |
| The ERKs are a subfamily of the MAPKs that have been implicated in cell growth and differentiation. Extracellular signal-regulated kinase 8 (Erk8) is a large MAP kinase whose activity is controlled by serum and the c-Src non-receptor tyrosine kinase. ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5 and can negatively regulate transcriptional co-activation of androgen receptor and GRalpha by Hic-5 in a kinase-independent manner, suggesting a broader role for ERK8 in the regulation of nuclear receptors beyond estrogen receptor alpha. Erk8 is a novel effector of RET/PTC3 and, therefore, RET biological functions. Applications: Suitable for use in ELISA, Western Blot, and Immunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:50-1:100 Immunohistochemistry: 1:10-1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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