KB05yne is a site-selective, alkyne-functionalized electrophilic fragment probe, crafted for covalent ligand discovery with preferential reactivity towards specific cysteine residues in proteins. It robustly labels wild-type target proteins (such as CDKN2AIP, HPCAL1) but not their cysteine-to-alanine mutants, confirming site-specific cysteine reactivity. KB05yne is utilized in the discovery and optimization of site-specific covalent ligands for a range of structurally and functionally diverse proteins, particularly in studying cysteine residues within cancer-related or hard-to-purify proteins.
Molekulargewicht:
425.33
CAS Nummer:
[2724919-69-9]
Formel:
C22H21BrN2O2
Target-Kategorie:
Others
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
