VLPDVFIRCV, a peptide derived from a melanoma antigen, originates from the intronic sequence (nt 38-67) of the N-acetylglucosaminyltransferase V (GnT-V) gene. Despite its high binding affinity for MHC-I molecules, VLPDVFIRCV does not activate an immune response against natural tumor cells. However, cytotoxic T lymphocytes (CTL) induced by VLPDVFIRCV can specifically lyse T2 cells loaded with this peptide in chromium release assays. This peptide is useful for research in vaccine design.
Molekulargewicht:
1160.44
CAS Nummer:
[176510-49-9]
Formel:
C54H89N13O13S
Target-Kategorie:
MHC
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