FOG-001 is an efficient inhibitor of beta-catenin, with an IC50 value lower than 50 nM. This compound can block the interaction between beta-catenin and T-cell factor (TCF) transcription factors, thereby interfering with the related signaling pathways. FOG-001 can effectively inhibit cell proliferation and induce cell cycle arrest. In a mouse xenograft tumor model carrying COLO320DM colon cancer cells (with APC and TP53 mutations), FOG-001 exhibits significant anti-tumor activity. Therefore, FOG-001 is applicable to the research on the mechanism of colon cancer occurrence and treatment.
Molekulargewicht:
2076.39
CAS Nummer:
[3044032-95-0]
Formel:
C102H134N18O25S2
Target-Kategorie:
Wnt/beta-catenin
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
