GNE-140 is a novel and potent lactate dehydrogenase A (LDHA) inhibitor that disrupts glycolytic metabolism in MIA PaCa-2 human pancreatic cancer cells, inducing rapid metabolic reprogramming prior to delayed cell death, with intrinsic resistance observed in OXPHOS-dependent pancreatic cell lines that can be reversed by phenformin, while acquired resistance is driven by AMPK-mTOR-S6K pathway activation, highlighting its value for studying metabolic plasticity and therapeutic resistance.
Molekulargewicht:
499.04
Reinheit:
98.43%
CAS Nummer:
[1809794-70-4]
Formel:
C25H23ClN2O3S2
Target-Kategorie:
Dehydrogenase
T27421
T27421
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