UniPR129 is a highly selective, cell-permeable, competitive Eph/ephrin antagonist belonging to the class of L-tryptophan derivatives of lithocholic acid. UniPR129 inhibits the interaction between EphA2 and ephrin-A1 with an IC50 of 945 nM and a Ki of 345 nM. UniPR129 inhibits angiogenesis in HUVEC cells with an IC50 of 5.2 µM. UniPR129 exhibits antitumor and neuroprotective effects and can be used in research on cancer and neurological diseases.
Molekulargewicht:
576.81
CAS Nummer:
[1639159-47-9]
Formel:
C36H52N2O4
Target-Kategorie:
Ephrin Receptor
T26310
T26310
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