TNIK-IN-1 (Compound 1) is a potent inhibitor of Traf2 and Nck-interacting kinase (TNIK), with an IC50 of 65 nM. TNIK is a pivotal effector in the Wnt/beta-catenin signaling pathway, essential for the maintenance of cancer stem cell properties and cellular proliferation. As a lead molecule based on the 4-phenyl-2-phenylaminopyridine scaffold, TNIK-IN-1 demonstrates significant antitumor activity by blocking TNIK kinase function and disrupting oncogenic signaling cascades, making it a valuable tool for researching Wnt-driven malignancies.
Molekulargewicht:
395.43
Reinheit:
99.01%
CAS Nummer:
[933886-36-3]
Formel:
C19H17N5O3S
Target-Kategorie:
Wnt/beta-catenin
T26282
T26282
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