BI-9627 hydrochloride is a highly potent Na/H exchanger 1 (NHE1) inhibitor. In intracellular pH recovery assays and human platelet swelling assays, its IC50 values are 6 nM and 31 nM, respectively. It shows more than 30-fold selectivity over NHE2 and has no significant inhibitory effect on NHE3. BI-9627 hydrochloride can reduce the autophagy level of HTR-8/SVneo cells, significantly decrease the intracellular pH of human sperm, partially reverse the effect of DMA, and prolong the Ca recovery time in KO hiPSC-CMs. BI-9627 hydrochloride has a low risk of drug-drug interactions, exhibits favorable pharmacokinetic properties in rats and dogs, and demonstrates potent activity in an ex vivo heart model of ischemia-reperfusion injury.
Molekulargewicht:
392.8
Reinheit:
99.91%
CAS Nummer:
[1422252-46-7]
Formel:
C16H20ClF3N4O2
Target-Kategorie:
Autophagy|||Sodium Channel
T23800
T23800
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