PROTACJAK1/2 degrader-1 (Compound A8) is a selective JAK1/2 PROTAC degrader with DC50 values of 1.4 µM for JAK1 and 0.92 µM for JAK2. It effectively inhibits the release of NO, IL-6 (IC50= 12.89 µM), and TNF-alpha (IC50= 17.17 µM). This compound alleviates inflammatory responses and colon damage by hindering the JAK/STAT3 signaling pathway, making it useful for studying colitis.
Target-Kategorie:
STAT|||JAK|||TNF|||PROTACs|||Interleukin
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