WR 30090 (Compound 37) is a broad-spectrum antimalarial agent that operates independently of the classical antifolate pathway. It shows significant activity against various strains of Plasmodium falciparum, both chloroquine-sensitive and -resistant, notably effective against the highly resistant Vietnamese strain. In rodent malaria tests, WR 30090 demonstrated high activity with a minimum effective dose of 5 mg/kg and a minimum curative dose of 20 mg/kg. This compound is useful for studying acute malaria.
Molekulargewicht:
514.31
CAS Nummer:
[19160-62-4]
Formel:
C25H28Cl4N2O
Target-Kategorie:
Parasite
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