SET-12 is a highly active and selective antiparasitic agent against Leishmania amazonensis. It demonstrates outstanding activity against the promastigote form of the parasite, with an IC50 of 10.89 µM and a selectivity index (SI) of up to 12.1. Additionally, SET-12 is effective against intracellular amastigotes, with an IC50 of 3.81 µM and an SI that increases to 34.5. SET-12 also induces signs of apoptosis in the parasites, such as mitochondrial damage and the accumulation of reactive oxygen species (ROS).
Molekulargewicht:
359.47
CAS Nummer:
[2241572-39-2]
Formel:
C21H29NO4
Target-Kategorie:
Parasite|||Apoptosis|||ROS|||DNA/RNA Synthesis
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