Aurora kinase/HDAC-IN-1, CAS [[2727102-12-5]] Preis auf Anfrage
Artikelnummer:
TGM-T214435
Hersteller Artikelnummer:
T214435
Alternativnummer:
TGM-T214435-10MG,TGM-T214435-50MG
Hersteller:
TargetMol
Kategorie:
Biochemikalien
Aurora kinase/HDAC-IN-1 is an orally active dual-target inhibitor of Aurora kinase and HDAC. It inhibits Aurora A (IC50 = 116 nM), Aurora B (IC50 = 225 nM), HDAC1 (IC50 = 164 nM), and HDAC2 (IC50 = 346 nM). This compound enhances histone acetylation (Ac-H3), inhibits phosphorylation of Aurora A and its downstream signaling, and induces apoptosis through G2/M phase arrest. In colorectal cancer cells HCT-116, Aurora kinase/HDAC-IN-1 shows significant antiproliferative activity with an IC50 of 30.2 nM and effectively suppresses tumor growth in HCT-116 colorectal cancer xenograft mouse models.
Molekulargewicht:
449.51
CAS Nummer:
[2727102-12-5]
Formel:
C22H20FN7OS
Target-Kategorie:
HDAC|||Apoptosis|||Aurora Kinase
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