MST3-IN-1 TFA (Compound LD-1) is a selective and orally bioactive MST3 inhibitor with an IC50 value of 122.4 nM. It exhibits antiproliferative effects on HepG2 cells, effectively inducing apoptosis and arresting the cell cycle in the G2/M phase. Additionally, MST3-IN-1 TFA significantly suppresses tumor growth in a HepG2 xenograft mouse model, making it applicable for liver cancer research.
Target-Kategorie:
Hippo pathway|||Apoptosis|||Caspase|||Bcl-2 Family
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