TopoisomeraseII/EGFR-IN-2 (Compound 3) is an inhibitor targeting Topoisomerase IIalpha, with an IC50 of 0.122 µM, and EGFR-TKWT, with an IC50 of 16.8 µM. It suppresses the proliferation of HeLa and HepG2 cells, induces cell cycle arrest, and triggers apoptosis. Additionally, it upregulates caspase-3 and Bax while downregulating Bcl-2, making it a potential agent for the study of liver and cervical cancers.
Target-Kategorie:
EGFR|||Apoptosis|||Caspase|||Topoisomerase|||Bcl-2 Family
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