VS3 is an inhibitor of the YAP-TEAD interaction. By directly binding to the TEAD4 Interface 3 (Kd = 6 µM), VS3 disrupts the interaction between YAP and TEAD. It exhibits antiproliferative activity against HT29, HCT116, and A2780 cells. VS3 is useful for studying colorectal adenocarcinoma and ovarian cancer.
Molekulargewicht:
363.42
CAS Nummer:
[2576427-49-9]
Formel:
C21H21N3O3
Target-Kategorie:
YAP
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