KRASG12C IN-19, CAS [[2915282-32-3]] Preis auf Anfrage
Artikelnummer:
TGM-T214375
Hersteller Artikelnummer:
T214375
Alternativnummer:
TGM-T214375-10MG,TGM-T214375-50MG
Hersteller:
TargetMol
Kategorie:
Biochemikalien
KRASG12C IN-19 is a selective inhibitor of KRASG12C. It exhibits potent antiproliferative activity against the KRASG12C-mutant non-small cell lung cancer (NSCLC) cell line H358, with an IC50 of 7.6 nM, and effectively inhibits downstream ERK phosphorylation (IC50= 24.06 nM). It shows no significant inhibitory activity on KRASG12V and KRASG12D mutant cancer cells (PANC 1, Panc 03.27, AsPC 1, and GP2d cells) with IC50 values greater than 10,000 nM. KRASG12C IN-19 rapidly forms a covalent bond with KRASG12V-GDP, leading to dose-dependent inhibition of the downstream KRAS pathway. This compound is suitable for research on KRASG12C-driven cancers, including non-small cell lung cancer, pancreatic cancer, and colorectal cancer.
Molekulargewicht:
590.66
CAS Nummer:
[2915282-32-3]
Formel:
C33H31FN8O2
Target-Kategorie:
ERK|||ROS
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
