CZS-241 hydrochloride is an orally active, selective inhibitor of Polo-like Kinase 4 (PLK4) with an IC50 of 2.6 nM. It also inhibits TRKA, with an IC50 of 2.74 µM. CZS-241 hydrochloride induces apoptosis and arrests the cell cycle at the S/G2 phase. It demonstrates potent antiproliferative activity against leukemia cell lines while exhibiting safety in normal cell lines.
Target-Kategorie:
Trk receptor|||Apoptosis|||PLK
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