NIK-IN-3 is a potent, orally active inhibitor of NF-kappaB-inducing kinase (NIK) with an IC50 value of 5.2 nM. It effectively suppresses activation of the non-canonical NF-kappaB pathway and inhibits the secretion of pro-inflammatory cytokines, including TNF-alpha, IL-6, IL-1beta, and the chemokine CXCL12. NIK-IN-3 demonstrates significant anti-inflammatory effects in LPS-induced sepsis and DSS-induced colitis mouse models. This compound is applicable in inflammation-related research, such as studies on colitis.
Target-Kategorie:
Interleukin|||TNF|||NF-kappaB|||CXCR
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