BChE-IN-46 is a selective BChE inhibitor with the ability to penetrate the blood-brain barrier [eqBChE IC50 = 7.44 * 10 -5 µM, SI > 270,000, hBChE IC50 = 1.48 * 10 -3 µM]. It also exhibits COX-2 inhibitory activity (IC50 = 0.11 µM). BChE-IN-46 may offer neuroprotective effects, enhance acetylcholine levels, and improve cognitive dysfunction, anxiety, as well as learning and memory deficits. It is a potential candidate for the development of anti-Alzheimers disease drugs.
Target-Kategorie:
Cholinesterase (ChE)|||COX
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