PDGFRalphakinase inhibitor 3 (Compound L7) is a potent inhibitor targeting the PDGFRalphaD842V kinase, exhibiting IC50 values of 23.8 nM in biochemical assays and 2.1 nM in cellular assays. It binds to the ATP binding site of PDGFRalphaD842V, blocking downstream signaling pathways and inhibiting kinase activity. PDGFRalphakinase inhibitor 3 is applicable in gastrointestinal stromal tumor (GIST) research.
Target-Kategorie:
PDGFR
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