5-HT4R agonist-2 (Compound 4) is a selective 5-HT4 receptor agonist with an EC50 of 0.41 nM. This compound significantly enhances intestinal and colonic transit, increases stool output and moisture content, while maintaining minimal systemic absorption, making it a promising candidate for research in chronic idiopathic constipation.
Target-Kategorie:
5-HT Receptor
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