JZ19 reduces intracellular levels of LDH and ROS and demonstrates antioxidant activity against oxygen-glucose deprivation (OGD)-induced myocardial cell damage. It reverses Isoproterenol-induced myocardial cell hypertrophy and apoptosis through the PI3K-AKT-GSK3beta signaling pathway. Additionally, JZ19 alleviates Isoproterenol-induced heart failure in mouse models.
Target-Kategorie:
Apoptosis|||GSK-3|||Akt|||PI3K
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