W23-1006 is a novel, selective, and cell-active covalent inhibitor of ALKBH5 (an m6A RNA demethylase). It functions by binding to the C200 residue of ALKBH5 with an IC50 value of 3.848 µM. W23-1006 demonstrates superior selectivity, being approximately 30-fold and 8-fold more potent against ALKBH5 than against FTO and ALKBH3, respectively. By inhibiting ALKBH5 and increasing global m6A abundance, W23-1006 effectively suppresses proliferation, migration, and colonization in triple-negative breast cancer (TNBC) cells.
Molekulargewicht:
418.2
CAS Nummer:
[3035498-92-8]
Formel:
C17H12BrN3O5
Target-Kategorie:
ALK
T205034
T205034
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