Vc-seco-DUBA (Duocarmazine) is a linker-payload conjugate designed for the synthesis of Antibody-Drug Conjugates (ADCs). It consists of the potent DNA alkylating payload DUBA (a duocarmycin analog) connected via the Vc-seco linker. This conjugate is engineered to enable the targeted delivery of highly cytotoxic DNA-alkylating agents specifically to tumor cells through antibody guidance. DUBA exerts its effect by binding to the minor groove of DNA and causing alkylation, which leads to DNA damage and subsequent apoptosis, demonstrating potent antitumor efficacy.
Molekulargewicht:
1331.81
CAS Nummer:
[1345681-58-4]
Formel:
C65H75ClN12O17
Target-Kategorie:
DNA Alkylation|||Apoptosis|||Drug-Linker Conjugates for ADC
T18362
T18362
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
