PF-5006739 is a potent and selective CK1delta/epsilon inhibitor with IC50 values of 3.9 nM and 17.0 nM, respectively.It can be used in the study of psychiatric disorders and exhibits low nanomolar in vitro potency against CK1delta/epsilon and high kinome selectivity.PF-5006739 dose-dependently reduces opioid-seeking behavior in rodent relapse models and improves glucose tolerance in mouse models of diet-induced obesity (DIO) and genetic obesity (ob/ob).
Molekulargewicht:
419.45
CAS Nummer:
[1293395-67-1]
Formel:
C22H22FN7O
Target-Kategorie:
Casein Kinase
T16507
T16507
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