M3258 is an immunoproteasome subunit LMP7 (beta5i) inhibitor, with an IC50 of 3.6 nM for LMP7 and 3.4 nM at the cellular level. In a multiple myeloma xenograft model, M3258 exhibits significant antitumor activity. In multiple myeloma cells, M3258 significantly and persistently inhibits LMP7 activity and ubiquitinated protein turnover in tumor tissues, further inducing apoptosis.
Molekulargewicht:
329.16
Reinheit:
99.91%
CAS Nummer:
[2285330-15-4]
Formel:
C17H20BNO5
Target-Kategorie:
Proteasome|||Apoptosis
T11924
T11924
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