A recombinant partial protein from human Inhibin alpha protein (within amino acids 233-362) was used as the immunogen for the Inhibin alpha chain antibody.
It recognizes a 47kDa protein, which is identified as alpha sub-unit of Inhibin. It is a gonadal protein that preferentially suppresses the secretion of pituitary follicle-stimulating hormone (FSH). Inhibin comprises two subunits, Inhibin A and Inhibin B. Each subunit consists of the same alpha subunit, covalently linked to 1 of 2 distinct subunits, beta-alpha or beta-beta. Inhibin belongs to the transforming growth factor beta (TFGb) superfamily. Antibodies against Inhibin are useful in making a differentiation between adrenal cortical tumors and renal cell carcinoma.
