CD103 Antibody / Integrin alpha E, Clone: [ITGAE/2474], Mouse, Monoclonal
Artikelnummer:
NSJ-V3837-20UG
Hersteller Artikelnummer:
V3837-20UG
Alternativnummer:
NSJ-V3837-20UG
Hersteller:
NSJ Bioreagents
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
IHC-P
Spezies Reaktivität:
Human
Immunogen:
A portion of amino acids 775-855 from the human protein was used as the immunogen for the CD103 antibody.
This antibody recognizes a protein of 150kDa, identified as CD103, which is the alpha-E integrin subunit of the heterodimeric alpha-E-beta-7 integrin belonging to a small beta-7 integrin subfamily. CD103 is expressed on more than 95% of intraepithelial CD8+ cells and on 40% of mucosa-associated T cells, whereas less than 2% of resting blood lymphocytes are CD103-positive. In several malignant conditions, such as T-cell lymphomas and hairy cell leukemia (HCL), the cells express CD103. This antibody is an extremely useful addition to the IHC panel for the diagnosis of hairy cell leukemia (HCL).
