An amino acid sequence from the middle region of human Receptor-interacting serine/threonine-protein kinase 1 (RRRRVSHDPFAQQRP) was used as the immunogen for this RIP antibody.
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1), also called RIP, is an enzyme that in humans is encoded by the RIPK1 gene. Members of the TRAF protein family have been implicated in the activation of NF-kappa-B by the TNF superfamily. By yeast 2-hybrid and coimmunoprecipitation studies using mammalian cell extracts, Hsu et al.(1996) showed that RIP interacts with TRADD, TRAF1, TRAF2, and TRAF3. Hartz(2012) mapped the RIPK1 gene to chromosome 6p25.2 based on an alignment of the RIP sequence with the genomic sequence. Stanger et al.(1995) found that overexpression of Rip in mammalian cells induced morphologic changes characteristic of apoptosis. They suggested that RIP may be an important element in the signal transduction machinery that mediates programmed cell death.
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Antibody Type:
Primary Antibody
Application Verdünnung:
Western blot: 0.5-1ug/ml
Anwendungsbeschreibung:
The stated application concentrations are suggested starting amounts. Titration of the RIP antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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