An amino acid sequence from the C-terminus of human Tuberous Sclerosis 1 (QLHIMDYNETHHEHS) was used as the immunogen for this TSC1 antibody (100% rat homology).
TSC1 (Tuberous Sclerosis 1), also called Hamartin, is a human protein and gene. As part of a comprehensive strategy to identify the gene mutant in tuberous sclerosis-1, van Slegtenhorst et al.(1997) developed an overlapping contig of clones from the 1.4-Mb TSC1 region on chromosome 9. Benvenuto et al.(2000) showed that overexpression of the TSC1 gene in rat fibroblasts inhibits growth and causes changes in cell morphology. Van Slegtenhorst et al.(1998) showed that hamartin and tuberin associate physically in vivo, however, and that the interaction is mediated by predicted coiled-coil domains.
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reinheit:
Antigen affinity
Formulierung:
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Antibody Type:
Primary Antibody
Application Verdünnung:
Western blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 0.5-1ug/ml
Anwendungsbeschreibung:
The stated application concentrations are suggested starting amounts. Titration of the TSC1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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