VDR Antibody (Vitamin D Receptor), Rabbit, Polyclonal
Artikelnummer:
NSJ-R31089
Hersteller Artikelnummer:
R31089
Alternativnummer:
NSJ-R31089
Hersteller:
NSJ Bioreagents
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
WB
Spezies Reaktivität:
Human, Mouse, Rat
Immunogen:
An amino acid sequence from the C-terminus of human Vitamin D Receptor (DLRSLNEEHSKQYRCL) was used as the immunogen for this VDR antibody.
Vitamin D Receptor, also known as Vitamin D Hormone Receptor, is a member of the nuclear receptor family of transcription factors. Labuda et al.(1991) assigned the VDR gene to 12q12-q14 by in situ hybridization. Using mutation analysis, Jurutka et al.(2000) characterized arg18/arg22, VDR residues immediately N-terminal of the first DNA-binding zinc finger, as vital for contact with the general transcription factor IIB(TFIIB). A natural polymorphic variant of the receptor, termed F/M4(missing a FokI restriction site), which lacks only the first 3 amino acids(including glu2), interacted more efficiently with TFIIB and also possessed elevated transcriptional activity compared with the full-length(f/M1) receptor. Shah et al.(2006) stated that the signaling and oncogenic activity of beta-catenin(CTNNB1) can be repressed by activation of VDR. Conversely, high levels of beta-catenin can potentiate the transcriptional activity of 1,25-dihydroxyvitamin D3.
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reinheit:
Antigen affinity
Formulierung:
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Antibody Type:
Primary Antibody
Application Verdünnung:
Western blot: 0.5-1ug/ml
Anwendungsbeschreibung:
The stated application concentrations are suggested starting amounts. Titration of the VDR antibody may be required due to differences in protocols and secondary/substrate sensitivity.
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
