A portion of amino acids 1-30 from the human protein was used as the immunogen for the Engrailed 1 antibody.
Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the engrailed (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system.
The stated application concentrations are suggested starting points. Titration of the Engrailed 1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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