The amino acids surrounding serine 78 of human Serum/glucocorticoid-regulated kinase 1 were used as the immunogen for the SGK1 antibody.
Serum/glucocorticoid-regulated kinase 1 is a serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis. Plays an important role in cellular stress response. Contributes to regulation of renal Na(+) retention, renal K(+) elimination, salt appetite, gastric acid secretion, intestinal Na(+)/H(+) exchange and nutrient transport, insulin-dependent salt sensitivity of blood pressure, salt sensitivity of peripheral glucose uptake, cardiac repolarization and memory consolidation.
The stated application concentrations are suggested starting points. Titration of the SGK1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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