A portion of amino acids 189-223 from human DNAJC3 was used as the immunogen for the DNAJC3 antibody.
DnaJ homolog subfamily C member 3 is involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity.
The stated application concentrations are suggested starting points. Titration of the DNAJC3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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