A partial recombinant protein corresponding to amino acids 188-375 from the human protein was used as the immunogen for the AGXT antibody.
Alanine glyoxylate aminotransferase is expressed only in the liver and is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targeting, have been associated with type I primary hyperoxaluria. [RefSeq]
