A portion of amino acids 302-332 from the human protein was used as the immunogen for the Factor VII antibody.
Coagulation factor VII (F7) initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. F7 is converted to F7a by factor Xa, XIIa, IXa, or thrombin by minor proteolysis. In the presence of tissue factor (TF) and calcium ions, F7a then converts F10 to F10a by limited proteolysis. F7a will also convert F9 to F9a in the presence of TF and calcium.
