A portion of amino acids 329-358 from human NR4A1 was used as the immunogen for this NUR77 antibody. (1)
NR4A1 is a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. This protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis.
Titration of the NUR77 antibody may be required due to differences in protocols and secondary/substrate sensitivity.1. This Ab will detect isoforms 1 and 2.
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