Cilazaprilat is an inhibitor of angiotensin-converting enzyme (ACE, IC50=0.7 nM for the rat enzyme) and an active metabolite of Cilazapril (HY-A0043). It decreases creatine kinase release in primary neonatal rat cardiac myocytes in an in vitro model of ischemia-reperfusion injury induced by hypoxia and reoxygenation when used at a concentration of 10 µM.3 Intra-arterial administration of cilazaprilat (3 µg/kg per minute) increases coronary blood flow and fractional shortening in a dog model of coronary hypoperfusion-induced myocardial ischemia.
Molekulargewicht:
389.45
CAS Nummer:
[90139-06-3]
Formel:
C20H27N3O5
Target-Kategorie:
Angiotensin-converting Enzyme (ACE)
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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