15(S)-Latanoprost is an analog of latanoprost in which the hydroxyl at carbon 15 is inverted relative to latanoprost. The IC50 values for the free acid forms of latanoprost and 15(S)-latanoprost were determined to be 3.6 nM and 24 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle. A 3 µg dose of 15(S)-latanoprost caused a 1 mmHg reduction of IOP in normotensive cynomolgus monkeys.
Molekulargewicht:
432.59
CAS Nummer:
[145773-22-4]
Formel:
C26H40O5
Target-Kategorie:
Prostaglandin Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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