Ancriviroc (SCH-351125) is an orally active CCR5 antagonist with an IC50 value of 13 nM against hCCR5. Ancriviroc specifically binds to hCCR5, blocks ligand-induced signal transduction, calcium influx, GTPgammaS binding, chemotaxis, ligand binding, and HIV-1 entry, induces conformational changes in CCR5, and inhibits infection and replication of R5-tropic HIV-1[1][2].
Molekulargewicht:
557.52
CAS Nummer:
[370893-06-4]
Formel:
C28H37BrN4O3
Target-Kategorie:
Calcium Channel,CCR,HIV
Anwendungsbeschreibung:
MCE Product type: Reference compound
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